Study: Same Nicotine Levels, but lower carcinogens exposure in e-cigs

e-cigarettes first reported on vaping and e-cigarettes in late July. We then quoted The Mash, a publication distributed to Chicagoland schools, which declared that “research from institutions like the Roswell Park Cancer Institute (RPCI) suggests that [it] may be true” that, as some users of e-cigs believe, “vaping is a safer alternative to smoking that [using] traditional cigarettes.”

Now, RPCI researchers have declared that, for e-cig users, “nicotine exposure remains the same, while exposure to specific carcinogens and toxicants is reduced,” among smokers who switch from tobacco cigarettes to electronic cigarettes. Their new research was published online ahead of print in the journal Nicotine Tobacco Research.

“To our knowledge, this is the first study with smokers to demonstrate that substituting tobacco cigarettes with electronic cigarettes may reduce exposure to numerous toxicants and carcinogens present in tobacco cigarettes,” says lead author Maciej Goniewicz, PhD, PharmD, Assistant Professor of Oncology in the Department of Health Behavior at Roswell Park. “This study suggests that smokers who completely switch to e-cigarettes and stop smoking tobacco cigarettes may significantly reduce their exposure to many cancer-causing chemicals.”

In a study conducted between March and June 2011, 20 healthy adult daily smokers were provided with electronic cigarettes and 20 tobacco-flavored cartridges. Participants in the study had smoked traditional cigarettes for an average of 12 years, and 95% of them said they planned to quit smoking. All participants were asked to substitute their usual tobacco cigarettes with e-cigarettes for two weeks.

The international scientific team measured participants’ urine levels of seven nicotine metabolites and 17 biomarkers of exposure to carcinogens and toxicants present in cigarette smoke over a two-week period. The biomarkers measured in the study are indicators of the risk of several diseases, including lung cancer. For 12 of 17 measured biomarkers, they found significant declines in exposure to toxicants when participants changed from tobacco cigarettes to e-cigarettes. The decline in toxicant levels was similar to the decline seen among tobacco users who quit smoking. Nicotine metabolites remained unchanged among the majority of study participants, confirming findings from earlier laboratory studies showing that e-cigarettes effectively deliver nicotine to the blood.

“Our findings suggest that e-cigarette use may effectively reduce exposure to toxic and carcinogenic substances among smokers who completely switch to these products,” says co-author Neal Benowitz, MD, Professor of Medicine at the University of California, San Francisco. “Future research will help determine whether e-cigarettes reduce the risk of disease among dual users — those who both smoke and vape — and those who use electronic cigarettes for a long time.”

The study, “Exposure to nicotine and selected toxicants in cigarette smokers who switched to electronic cigarettes: a longitudinal within-subjects observational study,” is available at

This work was supported by the Ministry of Science and Higher Education of Poland (grant no. NN404025638) and the U.S. National Institutes of Health (award nos. P30DA012393, National Institute on Drug Abuse, and S10RR026437, National Center for Research Resources). Dr. Goniewicz received a research grant from Pfizer, a pharmaceutical company that markets smoking-cessation medications. He and Benowitz have been consultants to pharmaceutical companies that market smoking cessation medications, and Dr. Benowitz has been an expert witness in litigation against tobacco companies.


Smoking Rates Dropped Significantly During Obama’s Administration

no smoking sign

The steady decline in smoking rates among U.S. adults that began in the early 1960s has accelerated substantially during the 7 years of the Barack Obama presidency. Since 2009, the prevalence of cigarette smoking in the United States has fallen at a rate of about 0.78 percentage points per year — more than double the rates observed during the administrations of Bill Clinton and George W. Bush (mean decreases of 0.28 and 0.36 percentage points per year, respectively, according to a report this week in The New England Journal of Medicine.

If the current rate of decline were to continue, the article said, the prevalence of smoking among U.S. adults would fall from its current level of 15.3% to zero by around 2035. In contrast, at the slower rates of decline observed during the Clinton and Bush years, smoking would not reach zero until approximately 2070 and 2057, respectively.

(Although cigarettes account for most of the combustible tobacco products sold in the United States, sales of non-cigarette tobacco products such as cigars have not decreased at the same rates.)

The recent accelerated decrease in cigarette smoking has not occurred in a vacuum. The striking decline since 2009 is most likely due to the implementation of an array of tobacco-control interventions at the federal, state, nonprofit, and private-sector levels.

These interventions, particularly those at the federal level, were highly intentional, well planned, and well organized. During the first 2 years of the Obama era, several legislative acts provided both the foundation and the essential tools for concerted action on tobacco control. Three of these new laws were particularly influential: the Children’s Health Insurance Program Reauthorization Act of 2009, which increased the federal cigarette excise tax rate from $0.39 to $1.01 per pack; the Family Smoking Prevention and Tobacco Control Act passed in June 2009, which gave the Food and Drug Administration (FDA) the authority to comprehensively regulate thousands of tobacco products for the first time; and the Affordable Care Act (ACA) passed in March 2010, which mandated insurance coverage of evidence-based smoking-cessation counseling and medications without barriers or copayments and expanded Medicare and Medicaid coverage for smoking-cessation treatments. The ACA also established the National Prevention Council and the Prevention and Public Health Fund. Other legislation that contributed included the American Recovery and Reinvestment Act (ARRA), the Prevent All Cigarette Trafficking Act, and the Health Information Technology for Economic and Clinical Health Act; these provided research funding, levied taxes on Internet sales of tobacco products, helped to reduce such sales to children, and incorporated assessment of tobacco use into “meaningful use” requirements for health information technology.

The Obama administration also advanced tobacco control through its leadership choices for the Department of Health and Human Services (HHS), including many senior appointees with extensive tobacco-control experience, such as Deputy Secretary of Health William Corr, Centers for Disease Control and Prevention (CDC) Director Tom Frieden, FDA Center for Tobacco Products (CTP) Director Mitch Zeller, and Assistant Secretary for Health Howard Koh.

All these appointees focused attention and energy on tobacco control. Koh, for instance, led the effort to develop the first HHS comprehensive strategic plan to confront tobacco use in America and created the HHS Tobacco Control Steering Committee, which brought together key HHS agencies each month to coordinate departmental actions designed to reduce tobacco use.

The HHS agencies involved (including the National Cancer Institute, the National Institute on Drug Abuse, the Centers for Medicare and Medicaid Services, and the Substance Abuse and Mental Health Services Administration) capitalized on the tools and opportunities made possible by the new legislation to greatly increase tobacco-control interventions. HHS directed $200 million from ARRA to launch Communities Putting Prevention to Work, a program that encouraged 22 cities and counties to implement evidence-based strategies to reduce tobacco use. In September 2011, the CDC awarded more than $100 million in prevention funding through a new program called Community Transformation Grants to aid states, communities, and tribes throughout the country in implementing tobacco-control programs. Both of these programs provided much needed funds as state and local tobacco-control funding was being reduced.

In March 2012, the CDC launched the first paid national tobacco-education campaign, “Tips from Former Smokers,” which features compelling stories of former smokers living with smoking-related diseases and disabilities. The CDC estimates that the Tips campaign has helped at least 400,000 smokers quit smoking for good since 2012 and is projected to help prevent at least 17,000 premature deaths.

The FDA’s CTP has been central to federal efforts including banning the manufacture and sale of fruit- or candy-flavored cigarettes; prohibiting the use of misleading claims such as “low,” “light,” and “mild”; issuing a final “deeming” regulation that extends its authority over tobacco products to include e-cigarettes, cigars, and pipe and hookah tobacco; conducting more than 600,000 retailer inspections to ensure compliance with laws restricting sales of tobacco products to young people, and issuing warning letters, monetary penalties, and prohibitions of tobacco sales for violations; requiring tobacco manufacturers to report the ingredients and levels of harmful and potentially harmful constituents in their products; and launching “The Real Cost” and other information campaigns warning young people of the dangers of tobacco products.

The cumulative effects of these legislative, regulatory, and policy actions may have resulted in a snowball effect — a decline in smoking that has accelerated over the Obama years. This progress has made the total elimination of tobacco use in the United States seem possible, rather than merely aspirational.

Capitalizing on this progress, the 50th-anniversary Surgeon General’s report, The Health Consequences of Smoking (2014), outlined a series of specific and feasible steps for eliminating tobacco use in America. The progress already made does not argue for future passivity; it argues for continued actions, ranging from sustaining national media campaigns to expanding the provision of tobacco-use counseling and medication treatments.

The path followed to reduce smoking rates during the Obama era provides a road map for the elimination of smoking in the United States. The past seven years have seen substantial progress, which suggests that the policies and programs implemented over this period have meaningfully reduced smoking prevalence. Obviously, there is no incontrovertible evidence linking the observed decreases in smoking with the administration’s actions and policies. However, other secular trends, such as economic changes and use of alternative tobacco products such as electronic nicotine delivery systems, do not seem substantial enough to account for the pronounced changes observed in cigarette smoking.

Despite this great progress, tobacco use continues to cause substantial harm in the United States, with about 15% of adults, or more than 36 million Americans, continuing to smoke. About half these people will die prematurely unless they can stop smoking.

Although an end to tobacco use in the United States now appears achievable, it will be realized only if we expand on the successful actions begun during the Obama era.